hEpAtIc irOn CONCenTrAtiOn

  • Hepatic Iron Concentration and Total Body Iron Stores in ...

    2000-8-3 · The hepatic iron concentration is a reliable indicator of total body iron stores in patients with thalassemia major. In patients with transfusion-related

  • Hepatic iron concentration and total body iron stores in ...

    The hepatic iron concentration is a reliable indicator of total body iron stores in patients with thalassemia major. In patients with transfusion-related iron overload, repeated determinations of the hepatic iron concentration can provide a quantitative means of

  • Hepatic iron concentration | Download Table

    Liver iron concentration is considered the surrogate marker of total body iron stores. Because liver biopsy is invasive and prone to high variability and sampling bias,

  • Hepatic Iron Concentration: Noninvasive Estimation by ...

    1999-7-1 · 10 Barry M. Liver iron concentration, stainable iron and total body storage iron. Gut 1974; 15:411-415. Crossref, Medline, Google Scholar; 11 Villeneuve JP, Bilodeau M, Lepage R, et al. Variability in hepatic iron concentration measurement from needle-biopsy specimens. J Hepatol 1996; 25:172-177. Crossref, Medline, Google Scholar

  • Hepatic iron concentration, fibrosis and response to ...

    The entire ferroportin coding region was sequenced and hepatic iron concentration, histology and response to treatment were determined. The results were compared with previously reported cases. The A77D mutation was detected in patient 1, his father (patient 2) and his brother (patient 3), who had portal fibrosis.

  • Determination of Hepatic Iron Concentration in Fresh and ...

    1999-4-1 · The mean liver iron concentration obtained was 3.36 mmol/kg (n = 30), with a CV of 4.2%. The precision of liver iron determination on embedded tissue was assessed by cutting a number of different size tissue samples from a single, relatively large histological sample.

  • Evaluation of hepatic iron concentration heterogeneities ...

    2019-7-1 · The variability of intra-hepatic iron concentrations can be evaluated using a MR T2* relaxometry method. • Hepatic iron concentration seems to be higher in the IV th segment in cases of higher iron deposition.. To measure liver iron load, a ROI could be placed in segment IV, and not, as in current practice, in the right liver.

  • Quantification of liver iron concentration using the ...

    2018-3-2 · Background: The quantification of liver iron concentration (LIC) is important for the monitoring of the body iron level in patients with iron overload. Conventionally, LIC is quantified through R2 or R2* mapping using MRI. In this paper, we demonstrate an alternative approach for LIC quantification through measuring the apparent susceptibility of hepatic vessels using

  • Increased hepatic iron concentration in nonalcoholic ...

    1998-2-1 · Activated hepatic stellate cells, the main cellular source of increased collagen production in liver injury, 36 have been shown to become activated in hemochromatosis in the absence of steatosis or histological inflammation at HIC as low as 60 mmol/g dry wt. 37 Hepatic iron overload can directly cause lipid peroxidation 38 and the products of ...

  • Hepatic Iron Concentration: Noninvasive Estimation by ...

    1999-7-1 · 10 Barry M. Liver iron concentration, stainable iron and total body storage iron. Gut 1974; 15:411-415. Crossref, Medline, Google Scholar; 11 Villeneuve JP, Bilodeau M, Lepage R, et al. Variability in hepatic iron concentration measurement from needle-biopsy specimens. J Hepatol 1996; 25:172-177. Crossref, Medline, Google Scholar

  • Determination of Hepatic Iron Concentration in Fresh and ...

    1999-4-1 · The mean liver iron concentration obtained was 3.36 mmol/kg (n = 30), with a CV of 4.2%. The precision of liver iron determination on embedded tissue was assessed by cutting a number of different size tissue samples from a single, relatively large histological sample.

  • 080300 Hepatic Iron Concentration and Total Body Iron

    2018-1-21 · HEPATIC IRON CONCENTRATION AND TOTAL BODY IRON STORES IN THALASSEMIA MAJOR Volume 343 Number 5 · 329 hepatic

  • Evaluation of hepatic iron concentration heterogeneities ...

    2019-7-1 · The variability of intra-hepatic iron concentrations can be evaluated using a MR T2* relaxometry method. • Hepatic iron concentration seems to be higher in the IV th segment in cases of higher iron deposition.. To measure liver iron load, a ROI could be placed in segment IV, and not, as in current practice, in the right liver.

  • (PDF) MR Quantification of Hepatic Iron Concentration

    To evaluate the accuracy of magnetic resonance (MR) imaging in the quantification of hepatic iron concentration. Between April 1999 and June 2001, 112 patients were recruited prospectively.

  • Increased hepatic iron concentration in nonalcoholic ...

    1998-2-1 · Activated hepatic stellate cells, the main cellular source of increased collagen production in liver injury, 36 have been shown to become activated in hemochromatosis in the absence of steatosis or histological inflammation at HIC as low as 60 mmol/g dry wt. 37 Hepatic iron overload can directly cause lipid peroxidation 38 and the products of ...

  • Hepatic iron concentration combined with long‐term ...

    2001-12-24 · Chemical liver biopsy iron concentration was determined ( Barry & Sherlock, 1971). Thirty‐two of these patients have been followed at the Whittington Hospital Thalassaemia clinic from the time of liver biopsy ( Table I). All patients had been on regular transfusion therapy to maintain a haemoglobin level > 10 g/dl and had received regular ...

  • Reproducibility of liver iron concentration estimates in ...

    2020-11-18 · 1 INTRODUCTION. Liver iron concentration (LIC) measurement is necessary for evaluation of a variety of iron-loading disorders including hereditary HFE hemochromatosis, thalassemia, sickle cell anemia, aplastic anemia, and myelodysplasia. 1, 2 Iron overload is a systemic disorder characterized by a high level of iron in the plasma and functional cells and

  • Hepatic iron stores and plasma ferritin concentration in ...

    The 95% prediction intervals for hepatic iron concentration, given the plasma ferritin, were so broad as to make a single determination of plasma ferritin an unreliable predictor of body iron stores. Variability resulting from factors other than iron status limits the clinical usefulness of the plasma ferritin concentration as a predictor of ...

  • Practical guide to quantification of hepatic iron with MRI ...

    2019-8-7 · Abstract Our intention is to demystify the MR quantification of hepatic iron (i.e., the liver iron concentration) and give you a step-by-step approach by answering the most pertinent questions. The following article should be more of a manual or guide for every radiologist than a classic review article, which just summarizes the literature. Furthermore, we provide important

  • Hepatic Iron Concentration: Noninvasive Estimation by ...

    1999-7-1 · 10 Barry M. Liver iron concentration, stainable iron and total body storage iron. Gut 1974; 15:411-415. Crossref, Medline, Google Scholar; 11 Villeneuve JP, Bilodeau M, Lepage R, et al. Variability in hepatic iron concentration measurement from needle-biopsy specimens. J Hepatol 1996; 25:172-177. Crossref, Medline, Google Scholar

  • Determination of Hepatic Iron Concentration in Fresh and ...

    1999-4-1 · The mean liver iron concentration obtained was 3.36 mmol/kg (n = 30), with a CV of 4.2%. The precision of liver iron determination on embedded tissue was assessed by cutting a number of different size tissue samples from a single, relatively large histological sample.

  • What is the role of hepatic iron concentration (HIC) in ...

    2021-11-2 · Hepatic iron concentration (HIC) could be slightly elevated, but the level of HIC in patients with hereditary hemochromatosis is much higher. Patients with chronic hepatitis C virus infection (HCV ...

  • (PDF) MR Quantification of Hepatic Iron Concentration

    To evaluate the accuracy of magnetic resonance (MR) imaging in the quantification of hepatic iron concentration. Between April 1999 and June 2001, 112 patients were recruited prospectively.

  • Measurement of Hepatic Iron Concentration

    Measurements of hepatic iron concentration were made at adjacent sites by a colorimetric assay. Random effects modeling showed wide intrahepatic variation in

  • Hepatic iron concentration combined with long‐term ...

    2001-12-24 · Chemical liver biopsy iron concentration was determined ( Barry & Sherlock, 1971). Thirty‐two of these patients have been followed at the Whittington Hospital Thalassaemia clinic from the time of liver biopsy ( Table I). All patients had been on regular transfusion therapy to maintain a haemoglobin level > 10 g/dl and had received regular ...

  • Evaluation of hepatic iron concentration heterogeneities ...

    The variability of intra-hepatic iron concentrations can be evaluated using a MR T2* relaxometry method. • Hepatic iron concentration seems to be higher in the IV th segment in cases of higher iron deposition.. To measure liver iron load, a ROI could be placed in segment IV, and not, as in current practice, in the right liver.

  • Relationship of hepatic iron concentration to ...

    Relationship of hepatic iron concentration to histochemical grading and to total chelatable body iron in conditions associated with iron overload R. J. Walker , J. P. G. Miller , I. W. Dymock , K. B. Shilkin , and Roger Williams

  • Value of liver iron concentration in healthy volunteers ...

    2020-10-21 · The majority of the studies showed a good correlation between iron concentration in the liver and T2 or T2* in patients with iron-overload diseases in the course of congenital hemochromatosis ...

  • Serum iron concentrations in non-iron induced acute liver ...

    2021-12-11 · Serum iron concentrations were not clinically or significantly different (median: 23 mcg/dL vs 27 mcg/dL, p=0.8). In this cohort of patients with non-iron induced acute liver injury, serum iron concentrations did not significantly change with the observed rise in aminotransferases. These data help to further characterize patterns of serum iron ...